Role of Topical Calcipotriol to Potentiate the Effect of Photochemotherapy (PUVA) in Treatment of Vitiligo

Introduction: Vitiligo is a specific, common, often heritable acquired disorder characterized by well-circumscribed milky white cutaneous macules and patches devoid of identifiable melanocyte. Treatment vitiligo, though quite frustrating, includes repigmentation therapies like Topical glucocorticoids, calcipotrieinene, PUVA (Psoralen + Ultraviolet Light A). The combination calcipotriol proves effective for management this condition. Objectives: To compare the effectiveness topical in treatment vitiligo. Materials Methods: This quasi experimental study was undertaken at Combined Military Hospital, Dhaka Cantonment, from March to October 2015. A total 32 patients suffering vitiligo diagnosed clinically confirmed Wood’s lamp examination were selected as population. Systemic PUVA, thrice weekly given but applied twice daily one side body other used nothing Topically. Response assessed every 4 weeks along with photographic record compared between two sides body. Results: During course treatment, plus treated showed considerably better improvement than only side. response Excellent; 37.8% (12/32), Good; 31.3% (10/32), Fair; 18.8% (6/32), Poor; 12.5% (4/32) whereas (4/32), 25% (8/32), 43.8% (14/32) (6/32) Conclusion: shown that concurrent potentiates efficacy fact achieves earlier pigmentation lower UVA dosage comparison therapy. JAFMC Bangladesh. Vol 18, No 1 (June) 2022: 23-25